RESOURCES

Current CMIDD resources focus on three main areas: Chemical Synthesis, Compound Purification, and Molecular Design.  These capabilities are being developed to help catalyze hit-to-lead and drug discovery processes to enable the development of biological discoveries into small molecule therapeutics.

Chemical Synthesis Resource

• Equipment for serial and parallel synthesis including small- to medium-sized libraries
• Capability to synthesize molecular probes up to 10’s of grams
• Robotics for sample clean-up (SPE) and parallel library reaction set up

Chemical Purification Resource

• High Throughput Agilent-based mass directed purification system and medium throughput preparative HPLC with integrated UV-Vis and ELS detection
• State of the art parallel compound drying systems
• Dedicated robotics for compound reformatting and assignment of desired compounds to assay-ready configurations

Molecular Design Resource

• Developing an integrated Pipeline Pilot-based cheminformatics workflow
• Effective communication of information between biologists, computational chemists, and medicinal chemists is a high priority
• Application of virtual screening and in-silico chemistry will be used to multiply the productivity of biologists and chemists